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Viele übersetzte Beispielsätze mit "leider" – Deutsch-Französisch Wörterbuch und Suchmaschine für Millionen von Deutsch-Übersetzungen. Übersetzung für 'leider' im kostenlosen Deutsch-Englisch Wörterbuch von LANGENSCHEIDT – mit Beispielen, Synonymen und Aussprache. leider übersetzen: unfortunately, unfortunately, unhappily. Erfahren Sie mehr.

The long-acting forms of these drugs must be injected every 2 to 4 weeks for effective treatment. Most patients with acromegaly respond to this medication.

In many patients, GH levels fall within one hour and headaches improve within minutes after the injection.

Octreotide and lanreotide are effective for long-term treatment. Octreotide and lanreotide have also been used successfully to treat patients with acromegaly caused by non-pituitary tumors.

Because octreotide inhibits gastrointestinal and pancreatic function, long-term use causes digestive problems such as loose stools, nausea, and gas in one third of patients.

In addition, approximately 25 percent of patients develop gallstones , which are usually asymptomatic. For those who are unresponsive to somatostatin analogues, or for whom they are otherwise contraindicated, it is possible to treat using one of the dopamine agonists , bromocriptine or cabergoline.

As tablets rather than injections, they cost considerably less. These drugs can also be used as an adjunct to somatostatin analogue therapy.

They are most effective in those whose pituitary tumours cosecrete prolactin. Side effects of these dopamine agonists include gastrointestinal upset, nausea, vomiting, light-headedness when standing, and nasal congestion.

These side effects can be reduced or eliminated if medication is started at a very low dose at bedtime, taken with food, and gradually increased to the full therapeutic dose.

Bromocriptine lowers GH and IGF-1 levels and reduces tumor size in fewer than half of patients with acromegaly.

Some patients report improvement in their symptoms although their GH and IGF-1 levels still are elevated.

The latest development in the medical treatment of acromegaly is the use of growth hormone receptor antagonists. The only available member of this family is pegvisomant Somavert.

By blocking the action of the endogenous growth hormone molecules, this compound is able to control disease activity of acromegaly in virtually all patients.

Pegvisomant has to be administered subcutaneously by daily injections. Combinations of long-acting somatostatin analogues and weekly injections of pegvisomant seem to be equally effective as daily injections of pegvisomant.

Surgery is a rapid and effective treatment, of which there are two alternative methods. The first method, a procedure known as endonasal transphenoidal surgery, involves the surgeon reaching the pituitary through an incision in the nasal cavity wall.

The wall is reached by passing through the nostrils with microsurgical instruments. The second method is transphenoidal surgery during which an incision is made into the gum beneath the upper lip.

Further incisions are made to cut through the septum to reach the nasal cavity, where the pituitary is located. Endonasal transphenoidal surgery is a less invasive procedure with a shorter recovery time than the older method of transphenoidal surgery, and the likelihood of removing the entire tumor is greater with reduced side effects.

Consequently, endonasal transphenoidal surgery is often used as a first option, with transphenoidal and other treatments, such as medicinal therapy or stereotactic radiosurgery , used to reduce the remaining adverse effects of the remaining tumor.

These procedures normally relieve the pressure on the surrounding brain regions and lead to a lowering of GH levels.

Success depends on the skill and experience of the surgeon. The success rate also depends on what level of GH is defined as a cure.

Complications of surgery may include cerebrospinal fluid leaks, meningitis , or damage to the surrounding normal pituitary tissue, requiring lifelong pituitary hormone replacement.

Even when surgery is successful and hormone levels return to normal, patients must be carefully monitored for years for possible recurrence.

More commonly, hormone levels may improve, but not return completely to normal. These patients may then require additional treatment, usually with medications.

Radiation therapy has been used both as a primary treatment and combined with surgery or drugs. It is usually reserved for patients who have tumor remaining after surgery.

These patients often also receive medication to lower GH levels. Radiation therapy is given in divided doses over four to six weeks.

This treatment lowers GH levels by about 50 percent over 2 to 5 years. Patients monitored for more than 5 years show significant further improvement.

Radiation therapy causes a gradual loss of production of other pituitary hormones with time. Loss of vision and brain injury, which have been reported, are very rare complications of radiation treatments.

No single treatment is effective for all patients. Treatment should be individualized depending on patient characteristics, such as age and tumor size.

If the tumor has not yet invaded surrounding brain tissues, removal of the pituitary adenoma by an experienced neurosurgeon is usually the first choice.

After surgery, a patient must be monitored long-term for increasing GH levels. If surgery does not normalize hormone levels or a relapse occurs, a doctor will usually begin additional drug therapy.

The current first choice is generally octreotide or lanreotide. Bromocriptine or cabergoline are much cheaper and easier to administer, however.

With both types of medication, long-term therapy is necessary because their withdrawal can lead to rising GH levels and tumor re-expansion.

Radiation therapy is generally used for patients whose tumors are not completely removed by surgery, for patients who are not good candidates for surgery because of other health problems, and for patients who do not respond adequately to surgery and medication.

Upon successful treatment, symptoms and complications generally improve substantially or disappear, including headaches, visual disturbances, excess sweating, and diabetes.

From Wikipedia, the free encyclopedia. Acromegaly Facial features of a person with acromegaly. The cheekbones are pronounced, the forehead bulges , the jaw is enlarged, and facial lines are prominent.

Compared with the hand of an unaffected person left , the hand of a person with acromegaly right is enlarged, with fingers that are widened, thickened and stubby, and with thicker soft tissue.

Mandibular overgrowth leads to prognathism , maxillary widening, teeth spacing and malocclusion. Brow ridge and forehead protrusion remaining after tumor removal and tissue swelling eliminated.

Lower jaw showing the classic spacing of teeth due to acromegaly. Archived from the original on 27 August Retrieved 20 August Fundamentals of Hand and Wrist Imaging.

Archived from the original on Growth Hormone Related Diseases and Therapy: A Molecular and Physiological Perspective for the Clinician.

Pathogenesis, Diagnosis and Treatment 2 ed. Fragments of Neurological History. Acromegaly before Pierre Marie". Journal of the history of the neurosciences.

Andrews' Diseases of the Skin: Harrison's Principles of Internal Medicine 19th ed. The Journal of Clinical Endocrinology and Metabolism. Offering exclusive content not available on RedTube.

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These patients often also receive medication to lower GH levels. Radiation therapy is given in divided doses over four to six weeks.

This treatment lowers GH levels by about 50 percent over 2 to 5 years. Patients monitored for more than 5 years show significant further improvement.

Radiation therapy causes a gradual loss of production of other pituitary hormones with time. Loss of vision and brain injury, which have been reported, are very rare complications of radiation treatments.

No single treatment is effective for all patients. Treatment should be individualized depending on patient characteristics, such as age and tumor size.

If the tumor has not yet invaded surrounding brain tissues, removal of the pituitary adenoma by an experienced neurosurgeon is usually the first choice.

After surgery, a patient must be monitored long-term for increasing GH levels. If surgery does not normalize hormone levels or a relapse occurs, a doctor will usually begin additional drug therapy.

The current first choice is generally octreotide or lanreotide. Bromocriptine or cabergoline are much cheaper and easier to administer, however.

With both types of medication, long-term therapy is necessary because their withdrawal can lead to rising GH levels and tumor re-expansion.

Radiation therapy is generally used for patients whose tumors are not completely removed by surgery, for patients who are not good candidates for surgery because of other health problems, and for patients who do not respond adequately to surgery and medication.

Upon successful treatment, symptoms and complications generally improve substantially or disappear, including headaches, visual disturbances, excess sweating, and diabetes.

From Wikipedia, the free encyclopedia. Acromegaly Facial features of a person with acromegaly. The cheekbones are pronounced, the forehead bulges , the jaw is enlarged, and facial lines are prominent.

Compared with the hand of an unaffected person left , the hand of a person with acromegaly right is enlarged, with fingers that are widened, thickened and stubby, and with thicker soft tissue.

Mandibular overgrowth leads to prognathism , maxillary widening, teeth spacing and malocclusion. Brow ridge and forehead protrusion remaining after tumor removal and tissue swelling eliminated.

Lower jaw showing the classic spacing of teeth due to acromegaly. Archived from the original on 27 August Retrieved 20 August Fundamentals of Hand and Wrist Imaging.

Archived from the original on Growth Hormone Related Diseases and Therapy: A Molecular and Physiological Perspective for the Clinician.

Pathogenesis, Diagnosis and Treatment 2 ed. Fragments of Neurological History. Acromegaly before Pierre Marie". Journal of the history of the neurosciences.

Andrews' Diseases of the Skin: Harrison's Principles of Internal Medicine 19th ed. The Journal of Clinical Endocrinology and Metabolism.

J Intensive Care Med. Archived from the original on 2 April Retrieved 5 March Archived from the original on 4 July Wrestling Archived at the Wayback Machine.

December 27, Shedding Light on a Rare Disease: Archived from the original on 29 May In love with a monster". Archived from the original on June 8, Retrieved 4 May Diseases of the endocrine system E00—E35 , — Hypoglycemia beta cell Hyperinsulinism G cell Zollinger—Ellison syndrome.

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